Background: Post-stroke cognitive impairment (PSCI) can be a challenging condition, yet promising interventions like intermittent theta burst stimulation (iTBS) have shown remarkable results for other cognitive disorders. This study explores the effectiveness of iTBS, particularly when applied to the left dorsolateral prefrontal cortex (DLPFC), in enhancing cognitive function in stroke patients.

Methods: A total of 58 PSCI patients were randomly divided into two groups: one receiving iTBS therapy (n=28), and the other undergoing sham stimulation (n=30). Both groups underwent standard cognitive-related rehabilitation alongside the interventions. The iTBS group received targeted treatment of the left DLPFC, while the sham group underwent similar procedures. Assessments were conducted at baseline (T0) and immediately after the intervention (T1) using the Mini-Mental State Examination (MMSE), Oxford Cognitive Screen, and event-related potential P300.

Results: Baseline clinical characteristics were similar between the groups. After the intervention, both groups exhibited significant improvements in MMSE scores and P300 amplitude, coupled with a reduced P300 incubation period. However, the iTBS group demonstrated significantly greater improvements (p < .05) compared to the sham stimulation group. Moreover, the iTBS group experienced more substantial enhancements in semantic comprehension and executive function (p < .05).

Conclusion: The results indicate that iTBS can safely and effectively enhance cognitive function in stroke patients, addressing overall cognitive impairment, including semantic understanding, executive function, and memory. The study calls for further research with larger sample sizes and long-term follow-up to validate these promising outcomes.

Experience the potential of TMS therapy at Countryside Neurology in Palm Harbor, FL. Our specialized team is committed to providing cutting-edge care for post-stroke cognitive impairment. To explore the transformative benefits of TMS therapy and advance your journey to cognitive recovery, contact us at 727-712-1567. Your path to renewed cognitive abilities begins in Palm Harbor, Florida.

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