What is progressive lateral sclerosis?

Progressive lateral sclerosis (PLS) is a type of motor neuron disease that affects the upper motor neurons (UMN), which control voluntary movements. PLS causes progressive weakness, stiffness, and muscle wasting in the limbs, as well as changes in speech and writing. There is no cure for PLS, and treatment is symptomatic, focusing on relieving symptoms and maintaining quality of life. The exact cause of PLS is unknown, but it is thought to result from a combination of genetic and environmental factors.
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